Roberto Chiesa Selected Research

Fatal Familial Insomnia

10/2022	Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes.
10/2021	Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice.
1/2021	Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells.
4/2015	Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.
1/2015	Preventive study in subjects at risk of fatal familial insomnia: Innovative approach to rare diseases.
9/2013	Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.

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Roberto Chiesa Research Topics

Disease

31	Aneurysm (Aneurysms) 07/2022 - 05/2006
26	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2022 - 08/2002
15	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2022 - 07/2003
15	Thrombosis (Thrombus) 04/2022 - 09/2004
15	Thoracoabdominal Aortic Aneurysm 03/2022 - 06/2007
13	Aortic Dissection 04/2022 - 10/2008
13	Endoleak 01/2021 - 09/2004
11	Abdominal Aortic Aneurysm 01/2022 - 12/2005
11	Infections 01/2021 - 05/2005
9	Ischemia 12/2020 - 07/2003
9	False Aneurysm (Pseudoaneurysm) 03/2020 - 08/2015
8	Rupture 01/2022 - 01/2004
7	Stroke (Strokes) 10/2022 - 09/2004
7	Pathologic Constriction (Stenosis) 02/2022 - 07/2008
7	COVID-19 06/2021 - 10/2020
7	Aortic Diseases 01/2021 - 01/2004
7	Hemorrhage 01/2021 - 11/2005
6	Fatal Familial Insomnia 10/2022 - 09/2013
5	Aortic Aneurysm (Aneurysm, Aortic) 04/2022 - 01/2020
5	Atherosclerosis 04/2021 - 01/2012
5	Carotid Stenosis (Carotid Artery Stenosis) 02/2021 - 09/2015
5	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2021 - 11/2008
5	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 08/2012
5	Aortic Rupture 04/2017 - 03/2012
5	Fistula 04/2012 - 05/2005
4	Pain (Aches) 04/2022 - 03/2012
4	Spinal Cord Ischemia 03/2022 - 07/2005
4	Hypertension (High Blood Pressure) 01/2022 - 01/2006
4	Acute Kidney Injury (Acute Renal Failure) 03/2021 - 07/2003
4	Paraplegia (Spastic Paraplegia) 01/2019 - 06/2004
4	Ulcer 01/2016 - 06/2011
4	Scrapie 01/2014 - 08/2002
3	Cerebrospinal Fluid Leak 06/2022 - 10/2008
3	Wounds and Injuries (Trauma) 05/2022 - 07/2006
3	Myocardial Infarction 12/2019 - 09/2015
3	Neurologic Manifestations (Neurological Manifestations) 01/2018 - 07/2005
3	Hematoma 01/2011 - 01/2006
2	Postoperative Pain 04/2022 - 01/2019
2	Renal Insufficiency (Renal Failure) 01/2021 - 11/2008
2	Cognitive Dysfunction 01/2021 - 02/2010
2	Hypoxia (Hypoxemia) 03/2019 - 07/2013
2	Memory Disorders (Memory Loss) 01/2019 - 11/2008
2	Neuroinflammatory Diseases 01/2019 - 01/2017
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 02/2004
2	Dementia (Dementias) 10/2017 - 08/2012
2	Brain Diseases (Brain Disorder) 10/2017 - 01/2016
2	Descending Thoracic Aortic Aneurysm 10/2016 - 07/2002
2	Thoracic Aortic Aneurysm 01/2016 - 06/2011
2	Marfan Syndrome (Marfan's Syndrome) 01/2016 - 02/2010
2	Chronic Limb-Threatening Ischemia 06/2013 - 11/2009
2	Sepsis (Septicemia) 01/2013 - 11/2008
2	Atherosclerotic Plaque (Atheroma) 01/2012 - 12/2006
2	Carotid Artery Diseases 03/2009 - 07/2008
2	Aortic Arch Aneurysm 07/2007 - 09/2004

Drug/Important Bio-Agent (IBA)

29	Prion ProteinsIBA 10/2022 - 08/2002
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2005
8	PrionsIBA 10/2022 - 08/2002
7	Protein Isoforms (Isoforms)IBA 10/2022 - 08/2002
4	Anti-Bacterial Agents (Antibiotics)IBA 12/2022 - 11/2008
4	MetalsIBA 06/2014 - 08/2006
3	Doxycycline (Periostat)FDA LinkGeneric 12/2022 - 01/2015
3	SolutionsIBA 06/2022 - 01/2015
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2015
3	AnticoagulantsIBA 06/2021 - 02/2012
3	Amyloid (Amyloid Fibrils)IBA 01/2021 - 08/2012
3	CytokinesIBA 10/2019 - 01/2013
3	allogenic effect factor (AEF)IBA 08/2016 - 04/2012
3	Peptides (Polypeptides)IBA 01/2016 - 08/2002
3	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2011 - 06/2003
2	Phenobarbital (Luminal)FDA Link 04/2022 - 07/2009
2	Crystalloid SolutionsIBA 08/2021 - 03/2014
2	Dental Implants (Dental Implant)IBA 01/2021 - 10/2012
2	Fibrinogen (Factor I)FDA Link 01/2021 - 01/2018
2	ethylene-vinyl alcohol copolymerIBA 07/2020 - 01/2020
2	(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)- 2,2- dimethylpropyl)- 2- (3,4- dimethoxyphenyl)acetamide)IBA 03/2019 - 01/2017
2	Metalloproteases (Metalloproteinases)IBA 03/2019 - 01/2017
2	nitinolIBA 01/2019 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2019
2	Biological ProductsIBA 08/2012 - 08/2002
2	Monoclonal AntibodiesIBA 01/2012 - 03/2005
2	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 09/2010 - 04/2010
2	Contrast MediaIBA 03/2009 - 07/2008
2	Peptide Hydrolases (Proteases)FDA Link 07/2003 - 08/2002

Therapy/Procedure

59	Stents 04/2022 - 01/2004
30	Endovascular Aneurysm Repair 07/2022 - 02/2009
18	Therapeutics 10/2022 - 07/2003
8	Vascular Surgical Procedures 05/2021 - 01/2020
8	Carotid Endarterectomy 01/2021 - 01/2006
8	Endovascular Procedures 02/2018 - 05/2005
6	Prostheses and Implants (Prosthesis) 11/2021 - 10/2012
5	Ligation 01/2022 - 05/2006
4	Surgical Amputation (Amputations) 02/2021 - 06/2013
3	Length of Stay 04/2022 - 06/2019
3	Punctures 01/2022 - 01/2018
3	Laparotomy 02/2018 - 08/2006
3	Endarterectomy (Thromboendarterectomy) 05/2015 - 06/2006
2	Blood Transfusion (Blood Transfusions) 01/2020 - 01/2019
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 11/2019 - 09/2004
2	Conservative Treatment 06/2019 - 01/2010
2	Aftercare (After-Treatment) 01/2017 - 04/2016